Fig. 13

Treatment bladder cancer by SCNTs/si-circPRMT5 nanocomplex. The SCNTs/si-circPRMT5 nanocomplex shields circPRMT5 siRNA from serum nuclease degradation and liver and renal clearance, thus promoting the accumulation of the circPRMT5 siRNA in tumor cells, leading to circPRMT5 silencing in bladder tumors. circPRMT5 downregulation retards the growth and progression of bladder cancer