Fig. 1

Schematic abstract of study. Polydopamine (PDA) was formed by self-polymerization of dopamine and coated on the surface of chitosan microspheres (CS). Then, 177Lu was chelated to PDA-CS microspheres by catechol groups and nano-MgO particles were modified on the surface to prepare 177Lu-PDA-CS-MgO microspheres. The radioactive microspheres were injected into rats through hepatic artery for embolization of primary HCC